Preparation of Ultra-thin Selenium Telluride Two-dimensional Material in Liquid Phase at Shenzhen Advanced Institute
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Figure: (left) Small cover image. (right) TEM images of selenium telluride nanosheets (a); photoacoustic imaging of selenium telluride at the tumor site (b); metabolism of selenium telluride in vivo (c); photothermal therapy in vivo (d).
Recently, researcher Yu Xuefeng of the Institute of Advanced Technology of the Chinese Academy of Sciences Shenzhen Institute of Technology collaborated with Professor Wang Tuquan of Wuhan University and Professor Zhu Jianhao of the City University of Hong Kong, and Xie Hanhan, a member of the research team, successfully prepared an ultra-thin 2D layered material for selenide telluride and applied it. Photoacoustic imaging guided photothermal therapy. The related paper Metabolizable Ultrathin Bi2Se3 Nanosheets in Imaging-Guided Photothermal Therapy has been published by the Nano Journal Small (DOI: 10.1002/smll.201601050) as a cover.
In recent years, graphene and other two-dimensional layered materials have attracted more and more attention because of their unique properties and broad application prospects. As a kind of two-dimensional layered material, bismuth selenide (Bi2Se3) has remarkable thermoelectric and optoelectronic properties. At the same time, it has good biological activity and biocompatibility, which has caused great interest among scientists. Particle size is critical to the functional optimization of two-dimensional layered materials, and two-dimensional materials with several atomic layer thicknesses often have very good electrical and optical properties. At the same time, in biomedical applications, particle size not only affects cell uptake and biocompatibility, but also affects its metabolism in the body. Therefore, how to prepare ultra-thin and ultra-small niobium selenide nano-sheets is a hot issue to be solved in current applications.
In response to this problem, the research group established a simple liquid-phase synthesis method and realized the large-scale preparation of antimony selenide. The obtained antimony selenide nano-sheet has a thickness of only 1.7 nm and a sheet size of about 31.4 nm. The study found that this ultra-thin selenide tellurium nanosheet has excellent near-infrared optical properties, the extinction coefficient at 808 nm is 11.5Lg-1cm-1, the photothermal conversion efficiency reaches 34.6%, and the photoacoustic conversion efficiency is also high. Optoacoustic guided tumor photothermal therapy can be realized and can be effectively metabolized out of the body. These studies demonstrate the great potential of this ultra-thin selenium germanium two-dimensional material in the field of biomedical photonics.
The project was funded by the Shenzhen Peacock Team Project and the Hong Kong Research Foundation’s Comprehensive Research Fund.
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