Application of supercritical carbon dioxide fluid extraction and separation
Supercritical carbon dioxide fluid extraction can be used for separation and purification of pharmaceutical, food, chemical and biological products.
1. Application in the pharmaceutical industry:
Supercritical carbon dioxide fluid extraction for the extraction of active ingredients of Chinese herbal medicine, purification of heat-sensitive biological products and separation of lipid mixtures, can prevent oxidation and escape of effective components of traditional Chinese medicine, without residual organic solvents, can obtain high quality The extract improves the utilization rate of the medicinal resources, greatly simplifies the extraction and separation steps, and can extract and separate some components which are not obtained by the conventional solvent method.
(1) The taxane component in the yew is extracted by the supercritical carbon dioxide method, and the obtained crude extract contains less impurities, and the monomer is more easily obtained.
(2) Spirulina is rich in protein and various biological active components. Supercritical carbon dioxide extraction and separation technology can extract the biologically active and thermolabile substances contained in spirulina and maintain its natural activity. The added value of spirulina products.
(3) Tanshinones are a general term for total ketones and other components extracted from Salvia miltiorrhiza, and are the main components for preparing various Danshen preparations. The extraction of tanshinones by supercritical carbon dioxide method has high yield, shortened production cycle and greatly improved active ingredients.
(4) The extraction of perilla oil and Cnidium by supercritical carbon dioxide method has high yield, short extraction time and high concentration of active ingredients.
(5) Using the supercritical carbon dioxide method to extract the traditional Chinese medicine compound, the active ingredient is highly concentrated, the impurities are less, and the appearance color is better.
2. Application in the food industry:
(1) Extraction of hops, pigments, etc. by supercritical carbon dioxide method.
(2) Extraction of β-carotene by supercritical carbon dioxide method has the advantages of high extraction efficiency, high speed, no pollution, simple process and pure color of extract.
3. Application in the chemical industry:
The supercritical carbon dioxide method is used for the synthesis and processing of polymer materials. The use of organic solvents does not avoid environmental pollution, and the process of desolvation and recovery of solvents is omitted, and the mechanical properties and processing properties of polymer materials can be improved. The size of the product is separated, the unreacted monomer can be recovered and the secondary reactant and the reactant impurities can be removed, and the polymer material can be dyed, flavored and modified by the supercritical multi-fluid.
4. Applications in the bio-industry:
Supercritical carbon dioxide is a non-polar reaction solvent, which can replace the fat-soluble organic solvent for enzymatic reaction. The fat-soluble reactant is soluble in supercritical carbon dioxide, while the enzyme is not dissolved. Some enzymes will have biological activity instead. Increase, can increase the reaction rate, which is conducive to the separation and purification of the product.
Supercritical carbon dioxide fluid extraction and separation technology is a separation technology developed in recent decades. It has the characteristics of low temperature operation, rapid, solvent-free residue and environmental friendliness. For those low-content, heat-sensitive and biologically active natural ingredients. The extraction shows a clear advantage.
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